Benhamou Research Group
Chemical Biology & Drug Design
About the lab
Our research laboratory focuses on the emerging role of RNA as a therapeutic target, positioned at the intersection of chemical biology, medicinal chemistry, and molecular/cellular biology. We leverage organic chemistry to address fundamental questions in RNA biology, with the aim of synthesizing and evaluating small molecules that bind to and modulate the function of specific RNA motifs in disease models. These small molecules serve as probes to explore RNA complexes or as potential drugs to alleviate disease-related phenotypes. Our work spans a broad range of pathologies, from genetic diseases like cancer to obesity, depression orinfectious diseases.
News & Events
24.12.2024: Excited to share our latest publication in Heliyon! Congrats to Elias on his work! - "Leveraging RIBOTAC Technology: Fluorescent RNase L Probes for Live-Cell Imaging and Function Analysis"
22.11.2024: New research article published in Macromolecular Bioscience - Congrats to Aseel and the team! - "PROTAC and Molecular Glue Degraders of the Oncogenic RNA Binding Protein Lin28"
20.11.2024: Research Webinar | Benhamou Lab - webinar showcasing our recent breakthroughs in developing small molecule therapies targeting RNA
01.10.2024: We welcome five new students to our lab: three new master's students—Liann, Leora, and Binyamin—and two undergraduate students, Hadas and Leen.
18.07.2024: Congratulations to Raphael for receiving the 2024 NCK medicinal chemistry prize for outstanding young chemist, Medicinal Chemistry Section of the Israel Chemical Society (MCS-ICS).
